tag:blogger.com,1999:blog-1829604838323083637.post5717585941086818832..comments2023-08-16T04:03:30.595-04:00Comments on Can U Talk About Genomics? (CUTAG): Animal GenomeKee Chan, PhDhttp://www.blogger.com/profile/12458864216039535394noreply@blogger.comBlogger63125tag:blogger.com,1999:blog-1829604838323083637.post-3785596521536678202014-04-24T14:17:41.834-04:002014-04-24T14:17:41.834-04:00One of the big limitations that I found with the o...One of the big limitations that I found with the original researchers dealth with their little knowledge of the disorders. Congenital myopathy disorders are not very well known period, where even less is known when discussing them in genetics. Zebrafish have been crucial in discovering the stac3 mutation and seeing how closely they are related to humans. The article was adequate in describing the research done. For my understanding, it was a little easier when reading because I was not bogged down with numbers and figures, and yet I was allowed to better comprehend the most important information. Alex Joynerhttps://www.blogger.com/profile/17789894299812322336noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-17306471265816114862013-12-10T13:30:51.974-05:002013-12-10T13:30:51.974-05:00The Science Daily article was clear and concise. ...The Science Daily article was clear and concise. It gave a great background to how the zebrafish are used to find a mutant gene in Native American myopathy. It was interesting how the scientists used the genetics and physiology of the zebrafish to understand the importance of the the Stac3 gene.<br />When comparing the actual study to Science Daily's summary, Science Daily does a decent job at summarizing the association of the zebra fish disease to Native American myopathy. Science Daily highlights some of the major findings of the study, including the association of the Stac3 gene. The article was intended to make the reader aware of a muscle disease and how it is related to the human genome and it does exactly as it intended, however it is a complex topic to understand if you have no prior experience in genetics. Caitlyn Burgesshttps://www.blogger.com/profile/16462831378793682212noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-34366307203065094582013-12-08T17:09:54.308-05:002013-12-08T17:09:54.308-05:00Overall I think Science Daily gave a good and to t...Overall I think Science Daily gave a good and to the point description of how zebrafish are being used to help identify a mutant gene in Native American myopathy. They made it simple and easy to understand and was clear and concise on what they were talking about. They however were too misleading and after reading the article, you did not get all the facts you needed to accurately asses the association between zebrafish and humans. One major limitation to this study was that zebrafish and humans are not that closely related. The other huge limitation stated was that the exact role of Stac3 is unknown in EC coupling and although there is knowledge behind Stac3 and human myopathy the exact correlation is unknown. There are a variety of mechanisms that can participate in the EC coupling so in order to use this gene as a way to help treat and diagnose humans the correlation needs to be correct. Laura Kodackhttps://www.blogger.com/profile/16925668423684581323noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-3364950823180635762013-12-08T13:28:36.715-05:002013-12-08T13:28:36.715-05:00The article in Science Daily, although gives a nic...The article in Science Daily, although gives a nice summary of the article presented in Nature Communications, does not give the more important details of the study. They focus only that the discovery in the Stac3 gene contributes to human myopathy however they failed to mention that both maternal and zygotic Stac3 genes were needed to have full immobility. <br /><br />When summarizing an article, it is important to give the gist of the article without missing information that can lead to misinterpretation of the article itself. Anonymoushttps://www.blogger.com/profile/13982987180643533637noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-57517415845246672652013-12-08T00:18:34.128-05:002013-12-08T00:18:34.128-05:00I think this article has a lot to offer for furthe...I think this article has a lot to offer for further research. I think the Science Daily review is pretty accurate in depicting the drawbacks and opportunities as a result of the study. The researchers mentioned the lack of myopathy drugs as a setback to the study but I think the information from this study will help spur further research and thus further drug development. Hopefully this new approach will open up the door further research in other diseases. Victoria Brownnoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-76583500453075841562013-12-08T00:02:08.141-05:002013-12-08T00:02:08.141-05:00The original researchers accounted for the fact th...The original researchers accounted for the fact that there isn't a lot of information currently available about this subject. Not many people have considered using the zebrafish, so this research is groundbreaking. <br />I thought this article was really interesting. I was concerned at first as to how studying a zebrafish could possibly help us treat a human genetic disorder - wouldn't we be too different? Fish and human? But the article briefly mentions as to why this could be possible. <br />I agree with my of my classmates above: science daily, although provided correct information and didn't skew any facts, did not provide a lot of details. In short, they provided incomplete information about the study. I can understand why they would, for most of their articles are around this length. But cutting out so much information could cause readers who don't know better to draw incorrect conclusions from this article. Angela Wangnoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-30573922979362588732013-12-08T00:00:53.223-05:002013-12-08T00:00:53.223-05:00The major limitations of this study are the overal...The major limitations of this study are the overall associations between zebra fish and humans. Just because zebra fish demonstrate similar gene deficiencies that result in the protein Stac3 not being encoded does not mean that zebra fish have genes comparable to humans. The article mentions that given the scope of degenerative muscle diseases, scientist do not know the genes responsible for the degenerative muscle diseases. The fact that Science Daily reported this information is very important because I believe it will allow readers to refrain from making the immediate association between the genomes of zebra fish and humans. Furthering the knowledge on the etiology of these disease will provide scientist with greater knowledge on the links between animal subjects and humans. Sarah Dillardhttps://www.blogger.com/profile/03071753955611069724noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-66106179343490093762013-12-07T23:53:11.480-05:002013-12-07T23:53:11.480-05:00This article was very interesting. However, upon r...This article was very interesting. However, upon reading about how they are using a myopathy in zebrafish to find a cure for a similar muscle weakness I was concerned why the scientists would think that they could compare zebra fish to humans. Though many cures and insights that we have now have come from NHP species, in the past, many inaccuracies that we held true for many years have also come from the use of NHP. My thought is that the scientists are taking a great leap of faith that they should further research especially because little is know about this myopathy in humans. This is what I believe to be their limitation. <br /><br />In addition I believe and agree with many of my classmates that science daily did not completely summarize the findings of the original article. Though what they have states is correct and simple to understand to the average person, it is incomplete and thus will lead many to jump to conclusions by using incomplete facts. Shani Ogilviehttps://www.blogger.com/profile/16396230231476149477noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-79912999037240338642013-12-07T23:48:35.788-05:002013-12-07T23:48:35.788-05:00The fact that there aren't a lot of drugs that...The fact that there aren't a lot of drugs that help with degenerative muscle disease is well accounted for by researchers. However it is pretty interesting that this gene was found in native Americans with myopathy, as knowing genetic aspects is always more helpful than trying to treat without it. It’s difficult to comprehend the conditions because there was a lack of details in the article. Lyse Barronvillehttps://www.blogger.com/profile/01588647619223810875noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-28841493608031348192013-12-07T23:30:33.460-05:002013-12-07T23:30:33.460-05:00It seems as though Science Daily has significantly...It seems as though Science Daily has significantly truncated the findings of the original researchers. They have chosen to highlight the potential benefits of the research instead of providing an unbiased and complete presentation of all the scientists have learned from their research. I wouldn't say the reporting is inaccurate, just simply incomplete. Briana Westnoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-84286181289983665432013-12-07T23:21:54.531-05:002013-12-07T23:21:54.531-05:00This is an interesting study that could lead to a ...This is an interesting study that could lead to a greater understanding of myopathy in the future. The identification of the mutation causing the disorder is only one piece of the puzzle and the rest of the disease is not understood completely at this point in time. If further studies build on this research then this will bring scientists closer to treatment and a cure for this rare disorder.Anonymoushttps://www.blogger.com/profile/06045557955705852730noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-3439541890845570502013-12-07T23:07:49.965-05:002013-12-07T23:07:49.965-05:00I think the purpose of the article on scientific d...I think the purpose of the article on scientific daily is fulfilled as it is just meant to be an overview of the research and it goes further than most websites - it actually links the journal! The title is not misleading, they do not go for a bravado headline like 'MYOPATHY CURED BY ZEBRAS OF THE SEA' and i think they give a good account of the research performed, without the nitty gritty - if you want that, read the journal on nature.com (and pay the $34 dollars).<br /><br />The major limitation the researchers face is the lack of understanding of myopathy. This is a step towards the discovery of a cure but it is clear there is a lot more work to be done.Samantha Pinheironoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-50680686307709569482013-12-07T22:56:27.160-05:002013-12-07T22:56:27.160-05:00I thought this study was quite fascinating, but th...I thought this study was quite fascinating, but the article seems incomplete. Scientists had trouble creating a drug specific for native americans with myopathy in North Carolina because they did not know the genes responsible. It was noticed that zebrafish have weak muscles reminiscent of myopathy in humans so they sequenced the zebrafish and found the gene mutation responsible for muscle weakness and decided to try to find the exact same gene in humans. It turned out that they found it and this helped pharmacogenetic companies to create a drug solution. The major limitation to the study that the researchers are accounting for are how a fish's genes could even relate to human genes. Their conclusions are too simplistic to what the actual study discovered. jensenhttps://www.blogger.com/profile/09344866712467402992noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-25556422070288582882013-12-07T22:47:05.872-05:002013-12-07T22:47:05.872-05:00The limitations which are mentioned are a lack of ...The limitations which are mentioned are a lack of knowledge on gene linkage to the diseases and also a lack of medicine to treat the muscle diseases. There is not enough information about the diseases to be able to treat them and with this gained knowledge, there can perhaps be some progress.<br />The article is summarized fairly well in science daily but it is very brief. I feel that if someone was to just read the article on science daily without researching the original article, they may be mislead due to the very short explanation of the gene and how much they actually know.Justine LaVoyenoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-57927013816862646472013-12-07T22:28:48.903-05:002013-12-07T22:28:48.903-05:00I think this article was interesting how they foun...I think this article was interesting how they found a link between such a specific fish and a specific race of humans. This article was brief so at first it was difficult to decipher what the initial limitations were. However, I think that it's that since the results are specific, they are hard to generalize. In addition, much more research needs to be done to back up this research, but it could be a promising beginning to degenerative diseases, even if it is only in a specific race, for now. Ashley Donahuenoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-91759217956164517572013-12-07T22:16:47.727-05:002013-12-07T22:16:47.727-05:00Vanessa Merta
Though this article was brief, I th...Vanessa Merta<br /><br />Though this article was brief, I think that it successfully explained the relationship between myopathy in humans and weak muscles in Zebrafish. I think the majority of the public would understand this article because of the terminology that they used, which is a great thing. So many people are unaware of tops such as this one that it is great to see that scientists are writing articles that can be understood by the everyday population. <br /><br />Like most of the class said, I think that the biggest limitation of this study is the lack of knowledge that we have now. This is a big step, but there is so much more to learn. The more we know the closer that we get to curing and treating degenerative muscle disorders. I think from here we just need more and more research on the topic, so eventually a treatment is found. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-10530797040330598992013-12-07T22:10:12.538-05:002013-12-07T22:10:12.538-05:00When I read the article in Science Daily, I could ...When I read the article in Science Daily, I could understand the objectives and findings of this study very easily. It was summarized with simple and basic terms. Also, the article was concise where I could understand important parts of the study very clearly.<br />However, I thought this study had a limitation. Muscle diseases are very broad field to just discover with one gene, Stac3. Also, finding one gene does not mean curing all muscle diseases. Researchers need to conduct more in-depth analysis to identify genes and treatment associated with muscle diseases. This is a good start to begin more research about genes associated with muscle diseases.<br />Haejin Hwanghttps://www.blogger.com/profile/08289466641037933352noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-43052125420586166212013-12-07T21:31:58.549-05:002013-12-07T21:31:58.549-05:00
The biggest limitation that the original research...<br />The biggest limitation that the original researchers accounted for is that there is little knowledge about degenerative muscle diseases. The genetic cause of myopathy is generally unknown, but progress has recently been made with the discovery of the mutant gene that encodes for Stac3, a protein that regulates a process required for muscle contraction. It was found that this gene was mutated in people who are suffering from Native American myopathy. This discovery will likely aid the future development of effective drugs for people who are afflicted with this disease.<br /><br />Science Daily provided an accurate snapshot of the original study, and is a helpful resource for those who are seeking a reputable summary about research. It was much more efficient for me to read the Science Daily article than the more complicated research study because I was simply interested in gaining a general understanding about the conclusions drawn by the scientists. It would have been helpful if Science Daily had gone into a bit more detail with the methods of the original study, so the reader would have a chance to evaluate the validity of the results.<br />Laura Donnellynoreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-63741576029012213872013-12-07T19:54:23.140-05:002013-12-07T19:54:23.140-05:00I think the biggest limitation of the study is tha...I think the biggest limitation of the study is that even though Stac3 is somehow associated with Native American myopathy, the exact role of Stac3 is still not clear. I think this is just the very beginning of understanding myopathy and the role of genetics in the disease. However, I think it is very interesting that we can look to the zebra fish genome to understand human physiology better. I believe that future research on Stac3 could lead to better understanding of myopathy and result in possible treatments. Also, with future research, other genes associated with the disease may be discovered.<br /><br />I think ScienceDaily did a great job summarizing the main points from the study. By writing in less technical terms, I think the majority of the public would understand the findings without having to have a background in genetics/biology. However, I also agree with Joseph that simplifying things may mislead the readers into thinking that this discovery will cure myopathy. In reality, while it is a crucial step in the process, a lot more research needs to be done before a potential drug/cure is found. Amanda Pottshttps://www.blogger.com/profile/07840830779234056070noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-70959652180681061392013-12-07T18:49:09.801-05:002013-12-07T18:49:09.801-05:00The Nature Communications article points out that ...The Nature Communications article points out that very little is known about myopathy in general. The genetic link has been created and the cause is known, but information on the exact process and what steps need to be done to create a viable disease is still far off.<br /><br />ScienceDaily does an excellent job of simplifying things. However, this simplifications creates an unsupported optimism. The format of the article is written to make the discovery seem pivotal, and a new discovery is imminent. In reality, while this discovery is remarkable and certainly a step, it is only one of many small findings that will need to be done until making a major discovery. Joseph Chohttps://www.blogger.com/profile/01223314749174642542noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-13634147248232094002013-12-07T18:05:15.575-05:002013-12-07T18:05:15.575-05:00ScienceDaily always does a fine job of simplifying...ScienceDaily always does a fine job of simplifying things so that laypersons can understand complex issues and this particular article does maintain accuracy in its simplicity.<br /><br />The biggest points in the Nature Communications article were that not much is known about degenerative muscle disease on the whole and that the Stac3 protein was their novel discovery. This gives special insight on Native American myopathy potentially leading to treatment, something that is currently less likely to be found for those other such diseases. ScienceDaily does cover these points but like many watered down science reports, the potential positive outcomes are a bit overemphasized.Anonymoushttps://www.blogger.com/profile/17182122086565472442noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-39383684332293350232013-12-07T17:45:06.405-05:002013-12-07T17:45:06.405-05:00The researchers definitely summarized the findings...The researchers definitely summarized the findings and association between the humans and Stac3 gene in zebrafish quite well. The one limitation from the study is that there is currently very few knowledge of degenerative diseases so they aren't able to develop drugs and other therapies targeting that specific disease. It is, however, good that they have finally found one gene to hopefully further their research. They are making progress and may eventually find a cure from the Stac3 gene from zebrafish. Anonymoushttps://www.blogger.com/profile/17950918001546953389noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-61680943589831614452013-12-07T16:25:51.998-05:002013-12-07T16:25:51.998-05:00In my opinion, the researchers’ conclusions are su...In my opinion, the researchers’ conclusions are summarized accurately. There were able to determine exactly what muscle protein the mutation codes for (Stac3). Along with their findings, they touched on the limitations. Since little is known about degenerative muscle conditions, this is a difficult branch of science to study. Most known degenerative muscle conditions do not have a cure, and few drugs work, like the article stated. At least scientists are now able to make progress and have identified the gene and are able to connect it to Native America myopathy. I find is fascinating that genes from a fish are able to help scientists learn more about certain genes in humans, especially genes accountable for such a complex, degenerating disorder. This further proves how closely connected different organisms and species are. Anonymoushttps://www.blogger.com/profile/05876708544024542531noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-52336070334479407462013-12-07T16:02:09.684-05:002013-12-07T16:02:09.684-05:00I think that The Science Daily article successfull...I think that The Science Daily article successfully summarizes the findings and the association between the Stac3 gene in zebrafish and humans to myopathy in Native Americans. That being said, I think a large problem with this study is the limitations that accompany the study. One major limitation is that there is a lack of knowledge of degenerative diseases because scientists are not able to pinpoint the causes of these diseases. With this lack of knowledge, the study will be significantly more difficult to conduct. The mechanism of how Stac3 acts in EC coupling is a good example of this. Although Stac3 was identified as a component of EC coupling, scientists are still unclear of its role in the pathway. This is the important information that could be used to diagnose, treat, manage and possibly cure degenerative diseases. Ali Reesehttps://www.blogger.com/profile/14915393668533265848noreply@blogger.comtag:blogger.com,1999:blog-1829604838323083637.post-92186985755287957332013-12-07T15:46:28.213-05:002013-12-07T15:46:28.213-05:00Science Daily highlights the major barrier in this...Science Daily highlights the major barrier in this study which is the general lack of knowledge surrounding the applicable conditions and diseases. Specifically, in regards to myopathy in Native Americans, the genome of zebrafish can be compared and applied to human pathologies and treatments. Scientists do not have a wide enough knowledge base about degenerative muscle disease, so these recent findings with zebrafish are expected to lead to new discoveries for such diseases. I think the article does a thorough job summarizing the findings and ensuring that the readers understand the main points and results of the study, as well as how it will apply to future research.Erin Yetterhttps://www.blogger.com/profile/12479612314645198835noreply@blogger.com